Theory and simulation of the ultrafast double-bond isomerization of biological chromophores

S Gozem, HL Luk, I Schapiro, M Olivucci - Chemical reviews, 2017 - ACS Publications
Ultrafast processes in light-absorbing proteins have been implicated in the primary step in
the light-to-energy conversion and the initialization of photoresponsive biological functions …

Recent advances in magic angle spinning solid state NMR of membrane proteins

S Wang, V Ladizhansky - Progress in nuclear magnetic resonance …, 2014 - Elsevier
Membrane proteins mediate many critical functions in cells. Determining their three-
dimensional structures in the native lipid environment has been one of the main objectives …

Enlightening the photoactive site of channelrhodopsin-2 by DNP-enhanced solid-state NMR spectroscopy

J Becker-Baldus, C Bamann… - Proceedings of the …, 2015 - National Acad Sciences
Channelrhodopsin-2 from Chlamydomonas reinhardtii is a light-gated ion channel. Over
recent years, this ion channel has attracted considerable interest because of its unparalleled …

Capturing peptide–GPCR interactions and their dynamics

A Kaiser, I Coin - Molecules, 2020 - mdpi.com
Many biological functions of peptides are mediated through G protein-coupled receptors
(GPCRs). Upon ligand binding, GPCRs undergo conformational changes that facilitate the …

The conformational equilibrium of the neuropeptide Y2 receptor in bilayer membranes

U Krug, A Gloge, P Schmidt… - Angewandte Chemie …, 2020 - Wiley Online Library
Dynamic structural transitions within the seven‐transmembrane bundle represent the
mechanism by which G‐protein‐coupled receptors convert an extracellular chemical signal …

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor

MT Eddy, ZG Gao, P Mannes, N Patel… - Journal of the …, 2018 - ACS Publications
Tryptophan indole 15N–1H signals are well separated in nuclear magnetic resonance
(NMR) spectra of proteins. Assignment of the indole 15N–1H signals therefore enables one …

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

MM Kogut‐Günthel, Z Zara, A Nicoli… - British Journal of …, 2024 - Wiley Online Library
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing
signals from the extracellular environment to the inside of the cell. They mediate the effects …

Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors

B Jin, N Thakur, AV Wijesekara, MT Eddy - Current Opinion in …, 2023 - Elsevier
G protein-coupled receptors (GPCRs) exhibit remarkable structural plasticity, which
underlies their capacity to recognize a wide range of extracellular molecules and interact …

Ligand channel in pharmacologically stabilized rhodopsin

D Mattle, B Kuhn, J Aebi, M Bedoucha… - Proceedings of the …, 2018 - National Acad Sciences
In the degenerative eye disease retinitis pigmentosa (RP), protein misfolding leads to fatal
consequences for cell metabolism and rod and cone cell survival. To stop disease …

Membrane mimetics for solution NMR studies of membrane proteins

KS Mineev, KD Nadezhdin - Nanotechnology Reviews, 2017 - degruyter.com
Membrane proteins are one of the most challenging and attractive objects in modern
structural biology, as they are targets for the majority of medicines. However, studies of …