Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell
physiology regulating several signal transduction pathways. They continuously …

Inter-organellar communication often takes the form of Ca2+ signals. These Ca2+ signals
originate from the endoplasmic reticulum (ER) and regulate different cellular processes like …

Intracellular Ca 2+ is a key regulator of cell signaling and sperm are not the exception. Cells
often use cytoplasmic Ca 2+ concentration ([Ca 2+] i) oscillations as a means to decodify …

HIV-associated neurological dysfunction is observed in more than half of the HIV-infected
population, even in the current antiretroviral era. The mechanisms by which HIV mediates …

The heteroreceptor complexes present a novel biological principle for signal integration.
These complexes and their allosteric receptor–receptor interactions are bidirectional and …

The purpose of this computational study was to investigate the possible role of voltage-gated
Ca 2+ channels in spontaneous Ca 2+ oscillations of astrocytes. By incorporating different …

In astrocytes, the intracellular calcium (Ca2+) signaling mediated by activation of
metabotropic glutamate receptor 5 (mGlu5) is crucially involved in the modulation of many …

Astrocytes are indispensable for proper neuronal functioning. Given the diverse needs of
neuronal circuits and the variety of tasks astrocytes perform, the perceived homogeneous …