[HTML][HTML] Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

S Nooraei, H Bahrulolum, ZS Hoseini… - Journal of …, 2021 - Springer
Virus-like particles (VLPs) are virus-derived structures made up of one or more different
molecules with the ability to self-assemble, mimicking the form and size of a virus particle but …

[HTML][HTML] Recent progress in targeted delivery vectors based on biomimetic nanoparticles

L Chen, W Hong, W Ren, T Xu, Z Qian… - Signal transduction and …, 2021 - nature.com
Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs)
since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological …

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

YH Chung, H Cai, NF Steinmetz - Advanced Drug Delivery Reviews, 2020 - Elsevier
Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …

[HTML][HTML] Virus-like particles as nanocarriers for intracellular delivery of biomolecules and compounds

J He, L Yu, X Lin, X Liu, Y Zhang, F Yang, W Deng - Viruses, 2022 - mdpi.com
Virus-like particles (VLPs) are nanostructures assemble from viral proteins. Besides widely
used for vaccine development, VLPs have also been explored as nanocarriers for cargo …

Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

S Hajebi, S Yousefiasl, I Rahimmanesh… - Advanced …, 2022 - Wiley Online Library
Conventional drug delivery systems are challenged by concerns related to systemic toxicity,
repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery …

Virus-like particles for drug delivery: a review of methods and applications

B Ikwuagwu, D Tullman-Ercek - Current Opinion in Biotechnology, 2022 - Elsevier
Highlights•Virus-like particles (VLPs) are versatile structuresfor drug-delivery applications.•
Mutations to VLP structural proteins can improve VLP drug delivery.•VLP–cargo loading …

[HTML][HTML] Yeast-based virus-like particles as an emerging platform for vaccine development and delivery

V Srivastava, KN Nand, A Ahmad, R Kumar - Vaccines, 2023 - mdpi.com
Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …

TLR Agonists Delivered by Plant Virus and Bacteriophage Nanoparticles for Cancer Immunotherapy

E Jung, YH Chung, NF Steinmetz - Bioconjugate Chemistry, 2023 - ACS Publications
Toll-like receptors (TLRs) are promising targets in cancer immunotherapy due to their role in
activating the immune system; therefore, various small-molecule TLR agonists have been …

Load and display: engineering encapsulin as a modular nanoplatform for protein-cargo encapsulation and protein-ligand decoration using split intein and SpyTag …

H Choi, S Eom, H Kim, Y Bae, HS Jung… - …, 2021 - ACS Publications
Protein cage nanoparticles have a unique spherical hollow structure that provides a
modifiable interior space and an exterior surface. For full application, it is desirable to utilize …

Overcoming biological barriers by virus-like drug particles for drug delivery

YL Chen, CJ Bao, JL Duan, Y Xie, WL Lu - Advanced Drug Delivery …, 2023 - Elsevier
Virus-like particles (VLPs) have natural structural antigens similar to those found in viruses,
making them valuable in vaccine immunization. Furthermore, VLPs have demonstrated …