Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The administration of drugs to the central nervous system (CNS) is primarily controlled by
the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds …

Although nanomedicine have greatly developed and human life span has been extended,
we have witnessed the soared incidence of central nervous system (CNS) diseases …

Inflammation, a common feature of many diseases, is an essential immune response that
enables survival and maintains tissue homeostasis. However, in some conditions, the …

Nose to brain drug delivery is considered as a viable option to deliver various therapeutic
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …

Abstract Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD),
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …

Viral infections are a great threat to human health. Currently, there are no effective vaccines
and antiviral drugs against the majority of viral diseases, suggesting the need to develop …

We previously developed a nose-to-brain delivery system using poly (ethylene glycol)-
polycaprolactone block polymeric micelles modified by a cell-penetrating peptide, Tat (PEG …

Alzheimer's disease (AD) remains the most prevalent neurodegenerative disease, and no
effective treatment is available yet. Metal‐ion‐triggered aggregates of amyloid‐beta (Aβ) …

The administration of liposomes via nose-to-brain delivery is expected to become a strategy
for efficient drug delivery to the central nervous system. Efficient nose-to-brain delivery and …