Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

The prevalence of obesity, measured by body mass index, has risen to unacceptable levels
in both men and women in the United States and worldwide with resultant hazardous health …

Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

A BMI in the normal range associates with a decreased risk of cardiometabolic disease and
all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared …

Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces
insulin resistance in peripheral insulin target tissues. Several mechanisms have been …

The extracellular matrix (ECM) is a network of different proteins and proteoglycans that
controls differentiation, migration, repair, survival, and development, and it seems that its …

Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …

The adipose tissue is crucial in regulating insulin sensitivity and risk for diabetes through its
lipid storage capacity and thermogenic and endocrine functions. Subcutaneous adipose …

In the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded
that an abdominal distribution of fat for a given BMI is associated with increased insulin …