The EGLN-HIF O2-sensing system: multiple inputs and feedbacks
M Ivan, WG Kaelin - Molecular cell, 2017 - cell.com
The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the
HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by …
HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by …
Prolyl 4-hydroxylase
KL Gorres, RT Raines - Critical reviews in biochemistry and …, 2010 - Taylor & Francis
Posttranslational modifications can cause profound changes in protein function. Typically,
these modifications are reversible, and thus provide a biochemical on-off switch. In contrast …
these modifications are reversible, and thus provide a biochemical on-off switch. In contrast …
[HTML][HTML] Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the
PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes …
PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes …
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling
J Adam, E Hatipoglu, L O'Flaherty, N Ternette… - Cancer cell, 2011 - cell.com
The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose
inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It …
inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It …
Cullin-RING Ligases as attractive anti-cancer targets
The ubiquitin-proteasome system (UPS) promotes the timely degradation of short-lived
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …
Generating specificity and diversity in the transcriptional response to hypoxia
The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells.
The hypoxic-sensitive regulation of gene expression allows information about the oxygen …
The hypoxic-sensitive regulation of gene expression allows information about the oxygen …
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
C Loenarz, CJ Schofield - Trends in biochemical sciences, 2011 - cell.com
Pioneering work in the 1960s defined prolyl and lysyl hydroxylations as physiologically
important oxygenase-catalyzed modifications in collagen biosynthesis; subsequent studies …
important oxygenase-catalyzed modifications in collagen biosynthesis; subsequent studies …
A clearer view of the molecular complexity of clear cell renal cell carcinoma
IJ Frew, H Moch - Annual Review of Pathology: Mechanisms of …, 2015 - annualreviews.org
The von Hippel–Lindau (VHL) tumor suppressor gene is mutated as an early event in almost
all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer …
all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer …
Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing
JD Webb, ML Coleman, CW Pugh - Cellular and molecular life sciences, 2009 - Springer
This article outlines the need for a homeostatic response to alterations in cellular
oxygenation. It describes work on erythropoietin control that led to the discovery of the …
oxygenation. It describes work on erythropoietin control that led to the discovery of the …
VHL and hypoxia signaling: beyond HIF in cancer
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear
cell carcinoma of renal cancer (ccRCC). Its regulatory pathway involves the activity of E3 …
cell carcinoma of renal cancer (ccRCC). Its regulatory pathway involves the activity of E3 …