Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer
treatment. The metabolic reprogramming that accompanies the development of malignancy …

Chronic diseases are persistent health conditions that affect our quality of life, increase
morbidity and mortality, and are a global challenge. Further, the increasing prevalence of …

Glutaminase (GLS), which deaminates glutamine to form glutamate, is a mitochondrial
tetrameric protein complex. Although inorganic phosphate (Pi) is known to promote GLS …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Purpose: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the
accumulation of immature myeloid precursor cells. AML is poorly responsive to conventional …

Glutamate is a nonessential amino acid and a putative neurotransmitter. When its
consumption exceeds its synthesis, it becomes necessary to monitor its levels. Hence, a low …

Metabolic reprogramming is associated with re/activation and antagonism of androgen
receptor (AR) signaling that drives prostate cancer (PCa) progression to castration …

Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover.
Limiting the supply of macromolecular precursors by targeting enzymes involved in …

Context Prostate-specific membrane antigen (PSMA) is a promising, novel theranostic target
in advanced prostate cancer (PCa). Multiple PSMA-targeted therapies are currently in …

Metabolic reprogramming is a hallmark of cancer, which implements a profound metabolic
rewiring in order to support a high proliferation rate and to ensure cell survival in its complex …