Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2,
BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional …

The speckle-type POZ protein (SPOP) functions in the Cullin3-RING ubiquitin ligase (CRL3)
as a receptor for the recognition of substrates involved in cell growth, survival, and signaling …

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers
opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the …

Clinical development of bromodomain and extra‐terminal (BET) protein inhibitors differs
from the traditional course of drug development. These drugs are simultaneously being …

Cooperation between DNA, RNA and protein regulates gene expression and controls
differentiation through interactions that connect regions of nucleic acids and protein domains …

The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists
of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer …

Identifying proteins that function at replication forks is essential to understanding DNA
replication, chromatin assembly, and replication-coupled DNA repair mechanisms …

YEATS domain (YD) containing proteins are an emerging class of epigenetic targets in drug
discovery. Dysregulation of these modified lysine‐binding proteins has been linked to the …

Transcription elongation by RNA polymerase II (Pol II) has emerged as a regulatory hub in
gene expression. A key control point occurs during early transcription elongation when Pol II …