Exacerbation of hypoxic injury after restoration of oxygenation (reoxygenation) is an
important mechanism of cellular injury in transplantation and in myocardial, hepatic …

This article provides the first extensive documentation of the dose response features of pre-
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …

In Part I, hormetic doses of a variety of agents stimulated adaptive responses that
conditioned and protected cells against the subsequent toxicity resulting from a second …

We investigated the effect of sildenafil in protection against necrosis or apoptosis in
cardiomyocytes. Adult mouse ventricular myocytes were treated with sildenafil (1 or 10 μm) …

Ever since the discovery of free radicals, many hypotheses on the deleterious actions of
reactive oxygen species (ROS) have been proposed. However, increasing evidence …

Bradykinin (BK) mimics ischemic preconditioning by generating reactive oxygen species
(ROS). To identify intermediate steps that lead to ROS generation, rabbit cardiomyocytes …

Reactive oxygen species (ROS) and nitric oxide (NO) are implicated in induction of ischemic
preconditioning. However, the relationship between these oxidant signals and opening of …

The phosphodiesterase type-5 (PDE5) inhibitor, sildenafil, is the first drug developed for
treatment of erectile dysfunction in patients. Experimental data in animals show that …

Aims: Myocardial infarction (MI) is a leading cause of death globally. MicroRNAs (miRNAs)
have been identified as a novel class of MI injury regulators. Hydrogen sulfide (H2S) is a …

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. The
major pathological consequences of IHD arise from the detrimental effects of acute ischemia …