Redefining the battle against colorectal cancer: a comprehensive review of emerging immunotherapies and their clinical efficacy

S Shebbo, N Binothman, M Darwaish, HA Niaz… - Frontiers in …, 2024 - frontiersin.org
Colorectal cancer (CRC) is the third most common cancer globally and presents a significant
challenge owing to its high mortality rate and the limitations of traditional treatment options …

Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy

TK Nikolouzakis, E Chrysos, AO Docea, P Fragkiadaki… - Cancers, 2024 - mdpi.com
Simple Summary Colorectal cancer (CRC) has become one of the leading causes of cancer-
related morbidity and mortality worldwide. Immune checkpoint inhibitors (ICIs) and adoptive …

Evaluation of blood MSI burden dynamics to trace immune checkpoint inhibitor therapy efficacy through the course of treatment

E Veselovsky, A Lebedeva, O Kuznetsova… - Scientific Reports, 2024 - nature.com
Abstract Analysis of serial liquid biopsy (LB) samples has been found to be a promising
approach for the monitoring of tumor dynamics in the course of therapy for patients with …

Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells

T Yu, K Van der Jeught, H Zhu, Z Zhou… - Advanced …, 2024 - Wiley Online Library
Colorectal cancer (CRC) cells display remarkable adaptability, orchestrating metabolic
changes that confer growth advantages, pro‐tumor microenvironment, and therapeutic …

Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective

V Kaviyarasan, A Das, D Deka, B Saha… - International Journal of …, 2025 - Springer
Purpose Colorectal cancer (CRC) remains one of the leading causes of cancer-related
mortality worldwide. Metastatic colorectal cancer (mCRC) continues to present significant …

HIPK2 in Colon Cancer: A Potential Biomarker for Tumor Progression and Response to Therapies

A Verdina, A Garufi, V D'Orazi… - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Colon cancer, one of the most common and fatal cancers worldwide, is characterized by
stepwise accumulation of specific genetic alterations in tumor suppressor genes or …

Genetic drivers for inflammatory protein markers in colorectal cancer: a Mendelian randomization approach to clinical prognosis study

H Li, G Li, X Zhang, Y Wang - Nan Fang yi ke da xue xue bao …, 2024 - europepmc.org
Objective To explore the causal relationship between inflammatory protein markers and the
risk of colorectal cancer using a Mendelian randomization (MR) approach. Methods We …

直肠癌炎症蛋白因子的遗传驱动: 孟德尔随机化方法在临床预后研究中的应用

李和平, 李高桦, 张学华, 王亚楠 - Journal of Southern …, 2024 - pmc.ncbi.nlm.nih.gov
目的利用孟德尔随机化(MR) 方法, 探索炎症蛋白因子与直肠癌风险之间的因果关系,
为直肠癌的预防和治疗提供新的策略. 方法从全基因组关联分析(GWAS) 数据集中选取与直肠癌 …