Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency
throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the …

Hematopoietic stem cells (HSCs) produce most cellular energy through glycolysis rather
than through mitochondrial respiration. Consistent with this notion, mitochondrial mass has …

Cell fate determination requires faithful execution of gene expression programs, which are
increasingly recognized to respond to metabolic inputs. In particular, the family of α …

The electron transport chain promotes aspartate synthesis, which is required for cancer cell
proliferation. However, it is unclear whether aspartate is limiting in normal stem cells. We …

Cancer cells are metabolically similar to their corresponding normal tissues. Differences
between cancers and normal tissues may reflect reprogramming during transformation or …

Oxidative stress is related to ageing and degenerative diseases, including cancer. However,
a moderate amount of reactive oxygen species (ROS) is required for the regulation of …

Stem cells perform many different functions, each of which requires specific metabolic
adaptations. Over the past decades, studies of pluripotent and tissue stem cells have …

Quiescent and self‐renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than
on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance …