Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-
lowering effects, well-established safety profile, and relatively low cost. While metformin has …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

Metformin exerts its plasma glucose-lowering therapeutic effect primarily through inhibition
of hepatic gluconeogenesis. However, the precise molecular mechanism by which …

Metformin, a cheap and safe biguanide derivative, due to its ability to influence metabolism,
is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of …

Introduction Drugs targeting mitochondria are emerging as promising antitumor therapeutics
in preclinical models. However, a few of these drugs have shown clinical toxicity …

Background Mild-temperature photothermal therapy (mild-PTT) has emerged as a highly
promising antitumor strategy by triggering immunogenic cell death (ICD) to elicit both innate …

ABSTRACT Eukaryotic Translation Initiation Factor 5A (EIF5A) is a translation factor
regulated by hypusination, a unique posttranslational modification catalyzed by …

Simple Summary In the last two decades, the antidiabetic drugs, biguanides, have received
considerable interest owing to their presumed antitumor properties. A critical issue that has …