Filtration of molecules by nanometer-sized structures is ubiquitous in our everyday life, but our understanding of such molecular filtration processes is far less than desired. Until …
Recent developments in micro-and nanotechnologies made possible the fabrication of devices integrating a deterministic network of nanochannels, ie, with at least one dimension …
We studied the passage of DNA molecules, driven by an electric field, through a microfabricated channel with 90 nm size constrictions. DNA molecules were entropically …
J Fu, RB Schoch, AL Stevens, SR Tannenbaum… - Nature …, 2007 - nature.com
Microfabricated regular sieving structures hold great promise as an alternative to gels to improve the speed and resolution of biomolecule separation. In contrast to disordered …
This Review addresses methods for obtaining sequence information directly from unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …
The behavior of DNA molecules is observed in a nanofluidic device near the interface of two regions that produce different configuration entropies. An electric field is applied to drive the …
KD Dorfman - Reviews of Modern Physics, 2010 - APS
Picking up at the conclusion of Viovy's review of the physics of gel electrophoresis [J.-L. Viovy, Rev. Mod. Phys. 72, 813 (2000) 10.1103/RevModPhys. 72.813], this review …
The separation of macromolecules such as polymers and DNA by means of electrophoresis, gel permeation chromatography or filtration exploits size-dependent differences in the time it …
Abstract Theory and numerical simulations play a major role in the development of improved and novel separation methods. In some cases, computer simulations predict counterintuitive …