Nanodiscs: Game changer nano-therapeutics and structural biology tools

AO Elzoghby, O Samir, A Soliman, S Solomevich, M Yu… - Nano Today, 2023 - Elsevier
In recent years, engineering biocompatible HDL nanodiscs has garnered a great interest
with wide applications for for both drug delivery and structural biology. In this review, we …

Hydrogel-based therapeutic angiogenesis: An alternative treatment strategy for critical limb ischemia

Z Xing, C Zhao, S Wu, C Zhang, H Liu, Y Fan - Biomaterials, 2021 - Elsevier
Critical limb ischemia (CLI) is the most severe clinical manifestation of peripheral arterial
disease (PAD), resulting in the total or partial loss of limb function. Although the conventional …

Plaque macrophage‐targeting nanosystems with cooperative Co‐regulation of ROS and TRAF6 for stabilization of atherosclerotic plaques

Q Yang, H Jiang, Y Wang, X Leng… - Advanced Functional …, 2023 - Wiley Online Library
Chronic inflammatory microenvironment is the predominant milieu that promotes the
progression of atherosclerosis (AS). However, targeted regulation of the chronic …

Designing nanodiscs as versatile platforms for on-demand therapy

Q Mu, H Deng, X An, G Liu, C Liu - Nanoscale, 2024 - pubs.rsc.org
Nowadays, there has been an increasing utilization of nanomedicines for disease treatment.
Nanodiscs (NDs) have emerged as a novel platform technology that garners significant …

Neuregulin-1/PI3K signaling effects on oligodendrocyte proliferation, remyelination and behaviors deficit in a male mouse model of ischemic stroke

MY Cui, YQ Fu, ZL Li, Y Zheng, Y Yu, C Zhang… - Experimental …, 2023 - Elsevier
In this study, we investigated the effect of neuregulin-1 (NRG1) on demyelination and
neurological function in an ischemic stroke model, and further explored its neuroprotective …

Single-component nanodiscs via the thermal folding of amphiphilic graft copolymers with the adjusted flexibility of the main chain

T Nishimura, Y Hatatani, M Ando, Y Sasaki… - Chemical …, 2022 - pubs.rsc.org
Nanodiscs have attracted considerable attention as structural scaffolds for membrane-
protein research and as biomaterials in eg drug-delivery systems. However, conventional …

A surface‐tailoring method for rapid non‐thermosensitive cell‐sheet engineering via functional polymer coatings

J Baek, Y Cho, HJ Park, G Choi, JS Lee… - Advanced …, 2020 - Wiley Online Library
Cell sheet engineering, a technique utilizing a monolayer cell sheet, has recently emerged
as a promising technology for scaffold‐free tissue engineering. In contrast to conventional …

Synthetic High‐Density Lipoprotein‐Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma

C Yang, Y Li, Y Yang, Q Ni, Z Zhang… - Angewandte …, 2023 - Wiley Online Library
Immunotherapies have shed light on the treatment of many cancers, but have not improved
the outcomes of glioma (GBM). Here, we demonstrated that suppressor of cytokine signaling …

SP prevents T2DM complications by immunomodulation

SM Baek, K Kim, S Kim, Y Son, HS Hong, SY Yu - Scientific Reports, 2020 - nature.com
Type 2 diabetic mellitus (T2DM) is characterized by systemic inflammation and insulin
resistance due to obesity, and this leads to critical complications, including retinopathy and …

Pien Tze Huang accelerated wound healing by inhibition of abnormal fibroblast apoptosis in Streptozotocin induced diabetic mice

Y Yan, X Liu, Y Zhuang, Y Zhai, X Yang, Y Yang… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Diabetic foot ulcer is one of the most serious complications
of diabetes. Effective medical treatment regarding improvement of ulcer healing in patients is …