Endogenous prostaglandins (PGs), produced from arachidonic acid by the two isoforms of
cyclooxygenase (COX), play a pivotal role in maintaining mucosal integrity by modulating …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E 2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

Cardiovascular diseases are the leading cause of global deaths, and many risk factors
contribute to their pathogenesis. In this context, prostanoids, which derive from arachidonic …

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for
esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of …

Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …

Sodium butyrate (NaBu) is reported to play important roles in a number of chronic diseases.
The present work is aimed to investigate the effect of NaBu on angiotensin II (Ang II) …

Receptor and non-receptor tyrosine kinases are involved in multiple proliferative signalling
pathways. Imatinib, one of the first tyrosine kinase inhibitors (TKIs) to be approved …

Oxidative stress is considered to be involved in the pathophysiology of all cancers. In order
to evaluate the total oxidant/antioxidant status in patients with thyroid cancer and to …

Ethnopharmacological relevance Syzygium aromaticum L. volatile oil (clove oil) has been
traditionally used for various stomach disorders including inflammatory conditions. Eugenol …

Prostaglandin E2 (PGE 2), a major product of cyclooxygenase, exerts its functions by
binding to four G protein-coupled receptors (EP1–4) and has been implicated in modulating …