Worldwide, lung cancer is the most common cause of cancer-related deaths. Molecular
targeted therapies and immunotherapies for non-small-cell lung cancer (NSCLC) have …

Traditional pathology approaches have played an integral role in the delivery of diagnosis,
semi-quantitative or qualitative assessment of protein expression, and classification of …

PURPOSE In the phase III CheckMate 067 trial, durable clinical benefit was demonstrated
previously with nivolumab plus ipilimumab and nivolumab alone versus ipilimumab. Here …

Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to
the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer …

Liver metastasis is highly aggressive and treatment-refractory, partly due to macrophage-
mediated immune suppression. Understanding the mechanisms leading to functional …

Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC …

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the
treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a …

Cancer immunotherapy is a validated and critically important approach for treating patients
with cancer. Given the vast research and clinical investigation efforts dedicated to advancing …

PURPOSE In KEYNOTE-189, first-line pembrolizumab plus pemetrexed-platinum
significantly improved overall survival (OS) and progression-free survival (PFS) compared …