There currently is no consensus on which immunological mechanisms can best explain the
rise in atopic disease post industrialization. The hygiene hypothesis lays groundwork for our …

Abstract Development of childhood asthma is complex with a strong interaction of genetic,
epigenetic, and environmental factors. Ultimately, it is critical how the immune system of a …

Background Latent toxoplasmosis, ie a lifelong infection with the protozoan parasite
Toxoplasma gondii, affects about a third of the human population worldwide. In the past 10 …

We evaluated the influence of the Toll-like receptor (TLR)-4 pathways on BeWo, JEG-3 and
HTR-8/SVneo cells, as well as in human villous explants infected with Toxoplasma gondii …

Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan causing several forms of
toxoplasmosis in humans. The main mechanisms that allow the development of the …

Allergic asthma is a chronic inflammatory disease mediated by Th2 cell immune responses.
Currently, immunotherapies based on immune deviation are attractive, preventive, and …

Sepsis is a severe syndrome that arises when the host response to an insult is exacerbated,
leading to organ failure and frequently to death. How a chronic infection that causes a …

Serine-proteases are important players in the pathogenesis of asthma, promoting
inflammation and tissue remodeling. It's also known that many serine protease inhibitors …

The increased prevalence of allergies in developed countries has been attributed to a
reduced exposure to some microbes. In agreement with epidemiological studies, we …

Background: The immunomodulatory role of many parasites is well-documented. The
current study designed to assess the immunoregulatory effects of the somatic extract (SE) of …