Population pharmacokinetic analysis is used to estimate pharmacokinetic parameters and
their variability from concentration data. Due to data sparseness issues, available datasets …

Developmental pharmacology describes the impact of maturation on drug disposition
(pharmacokinetics, PK) and drug effects (pharmacodynamics, PD) throughout the paediatric …

Model-informed precision dosing (MIPD) software tools are used to optimize dosage
regimens in individual patients, aiming to achieve drug exposure targets associated with …

Morphine is the opioid most commonly used for neonatal pain management. In intravenous
form, it is administered as continuous infusions and intermittent injections, mostly based on …

Inadequate pain and/or stress management in preterm‐and term‐born infants has been
associated with increased morbidity and even mortality. However, exposure to …

Providing maximal therapeutic efficacy without toxicity is a universal goal of rational drug
therapy. However, substantial between‐patient variability in drug response often impedes …

In premature infants, effective and safe drug therapy depends on optimal dose selection and
requires a thorough understanding of the underlying disease (s) of these fragile infants as …

Objective Morphine is a commonly used drug in encephalopathic neonates treated with
therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of …

Introduction: Pharmacologic pain management in newborns and infants is often based on
limited scientific data. To close the knowledge gap, drug-related research in this population …

Several population pharmacokinetic (PPK) models have been established to optimize the
therapeutic regimen and reduce the toxicity of high-dose methotrexate (HDMTX) in patients …