Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Purpose: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …

Transposable elements (TEs) comprise a group of repetitive sequences that bring positive,
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …

Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …

The genetic material of every organism exists within the context of regulatory networks that
govern gene expression, collectively called the epigenome. Epigenetics has taken center …

Ionizing radiation exposure from medical diagnostic imaging has greatly increased over the
last few decades. Approximately 80% of patients who undergo medical imaging are …

Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons are the major repetitive
elements in mammalian genomes. LINE-1s are well-accepted as driving forces of evolution …

Background Environmental exposure, medical diagnostic and therapeutic applications, and
industrial utilization of radionuclides have prompted a growing focus on the risks associated …

Aside from the generally accepted potential to cause DNA damage, it is becoming
increasingly recognized that ionizing radiation has the capability to target the cellular …

The aim of the present study was to investigate whether low‑dose priming radiation induces
antitumor immunity that can be augmented by the modulation of natural killer (NK) cell and …