Staphylococcus aureus is one of the leading hospital-associated and community-associated
pathogens, which has caused a global public health concern. The emergence of methicillin …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Animal production is associated with the frequent use of antimicrobial agents for growth
promotion and for the prevention, treatment, and control of animal diseases, thus …

Broad-spectrum β-lactam antibiotic resistance in Staphylococcus aureus is a global
healthcare burden,. In clinical strains, resistance is largely controlled by BlaR1, a receptor …

Although the peptidoglycan cell wall is an essential structural and morphological feature of
most bacterial cells, the extracytoplasmic enzymes involved in its synthesis are frequently …

The mechanism of the β-lactam antibacterials is the functionally irreversible acylation of the
enzymes that catalyze the cross-linking steps in the biosynthesis of their peptidoglycan cell …

Staphylococcus aureus infection of bone is challenging to treat because it colonizes the
osteocyte lacuno-canalicular network (OLCN) of cortical bone. To elucidate factors involved …

ABSTRACT Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight
penicillin-binding protein of Staphylococcus aureus, has been implicated in low-level …

Antimicrobial resistance in the environmental dimension is one of the greatest challenges
and emerging threats. The presence of resistant bacteria and resistance genes in the …

Methicillin-resistant Staphylococcus aureus (MRSA) causes serious community-acquired
and nosocomial infections worldwide. MRSA strains are resistant to a variety of antibiotics …