Sox transcription factors play many diverse roles during development, including regulating
stem cell states, directing differentiation, and influencing the local chromatin landscape. Of …

Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …

Neurodevelopmental disorders (NDDs) are a heterogeneous and highly prevalent group of
psychiatric conditions marked by impairments in the nervous system. Their onset occurs …

Automated detection of complex animal behaviors remains a challenging problem in
neuroscience, particularly for behaviors that consist of disparate sequential motions …

Ischemic stroke is a common clinical cardiovascular disease and often accompanied by
central nervous system injury. It often causes paralysis or loss of motor function after central …

Abstract Lamb–Shaffer Syndrome (LSS; OMIM# 616803; ORPHA# 313892; ORPHA#
313884) is an infrequent genetic disorder that affects multiple aspects of human …

Aims Deciphering the genetic relationships between major depressive disorder (MDD) and
osteoarthritis (OA) may facilitate an understanding of their biological mechanisms, as well as …

SOX6 belongs to a family of 20 SRY-related HMG-box-containing (SOX) genes that encode
transcription factors controlling cell fate and differentiation in many developmental and adult …

Copy number variations (CNVs) play a significant role in human disease. While
chromosomal microarray has traditionally been the first‐tier test for CNV detection, use of …

Lamb–Shaffer syndrome (LAMSHF) is a neurodevelopmental disorder caused by
heterozygous loss of function genetic alterations in SOX5, which result in haploinsufficiency …