The aim of this article is to present updated guidelines for the use of serum, tissue and faecal
markers in colorectal cancer (CRC). Lack of specificity and sensitivity preclude the use of all …

This article is one of a series of statements discussing the use of gastrointestinal endoscopy
in common clinical situations. The Standards of Practice Committee of the American Society …

Context Providing accurate estimates of cancer risks is a major challenge in the clinical
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a
common autosomal dominant syndrome characterized by early age at onset, neoplastic …

The utility of immunohistochemical detection of DNA mismatch repair (MMR) protein in
screening colorectal tumors for hereditary nonpolyposis colorectal cancer (HNPCC) …

PURPOSE: To compare microsatellite instability (MSI) testing with immunohistochemical
(IHC) detection of hMLH1 and hMSH2 in colorectal cancer. PATIENTS AND METHODS …

Purpose: The BRAF gene encodes a serine/threonine kinase and plays an important role in
the mitogen-activated protein kinase signaling pathway. BRAF mutations in sporadic …

ContextThe selection of individuals for hereditary nonpolyposis colorectal cancer (HNPCC)
genetic testing is challenging. Recently, the National Cancer Institute outlined a new set of …

Background The identification of mutations in germ-line DNA mismatch-repair genes at the
time of diagnosis of colorectal cancer is important in the management of the disease …

ContextIdentifying families at high risk for the Lynch syndrome (ie, hereditary nonpolyposis
colorectal cancer) is critical for both genetic counseling and cancer prevention. Current …