Co-stimulatory and co-inhibitory receptors have a pivotal role in T cell biology, as they
determine the functional outcome of T cell receptor (TCR) signalling. The classic definition of …

▪ Abstract Several members of the tumor necrosis factor receptor (TNFR) family function after
initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB …

Interactions between co-stimulatory ligands and their receptors are crucial for the activation
of T cells, the prevention of tolerance and the development of T-cell immunity. It is now …

Suppression of HIV replication by highly active antiretroviral therapy (HAART) often restores
protective pathogen-specific immune responses, but in some patients the restored immune …

Abstract Marek's disease (MD), caused by Marek's disease virus (MDV), is a commercially
important neoplastic disease of poultry which is only controlled by mass vaccination …

The persistence of functional CD8 T cell responses is dependent on checkpoints
established during priming. Although naive CD8 cells can proliferate with a short period of …

Ligands and receptors in the tumour necrosis factor (TNF) and tumour necrosis factor
receptor (TNFR) superfamilies have been the subject of extensive investigation over the past …

Animal models are essential for elucidating the molecular mechanisms of carcinogenesis.
Hodgkin's and many diverse non-Hodgkin's lymphomas overexpress the Hodgkin's disease …

The human enteric flora plays a significant role in intestinal health and disease. Certain
enteric bacteria can inhibit the NF-κB pathway by blockade of IκB-α ubiquitination. IκB-α …

CD30 is highly expressed on Hodgkins lymphoma and anaplastic large cell lymphoma,
making it an attractive target for therapy. We describe the generation of serum-stabilized …