Understanding nucleosome dynamics and their links to gene expression and DNA replication
WKM Lai, BF Pugh - Nature reviews Molecular cell biology, 2017 - nature.com
Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …
interactions at unprecedented spatial and temporal resolution. This has led to a profound …
Chromatin remodellers as therapeutic targets
HA Malone, CWM Roberts - Nature Reviews Drug Discovery, 2024 - nature.com
Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers
Genes encoding subunits of SWI/SNF (BAF) chromatin remodelling complexes are
collectively altered in over 20% of human malignancies, but the mechanisms by which these …
collectively altered in over 20% of human malignancies, but the mechanisms by which these …
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells
DNA–protein interactions regulate critical biological processes. Identifying proteins that bind
to specific, functional genomic loci is essential to understand the underlying regulatory …
to specific, functional genomic loci is essential to understand the underlying regulatory …
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …
Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
JH Elliott, F Wightman, A Solomon, K Ghneim… - PLoS …, 2014 - journals.plos.org
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation
SMARCB1 (also known as SNF5, INI1, and BAF47), a core subunit of the SWI/SNF (BAF)
chromatin-remodeling complex,, is inactivated in nearly all pediatric rhabdoid tumors …
chromatin-remodeling complex,, is inactivated in nearly all pediatric rhabdoid tumors …
Chromatin remodeling BAF (SWI/SNF) complexes in neural development and disorders
The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …
Vulnerabilities of mutant SWI/SNF complexes in cancer
KC Helming, X Wang, CWM Roberts - Cancer cell, 2014 - cell.com
Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers
are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding …
are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding …