Chronic wasting disease of cervids: current knowledge and future perspectives

NJ Haley, EA Hoover - Annu. Rev. Anim. Biosci., 2015 - annualreviews.org
A naturally occurring transmissible spongiform encephalopathy (TSE) of mule deer was first
reported in Colorado and Wyoming in 1967 and has since spread to other members of the …

The ecology of chronic wasting disease in wildlife

LE Escobar, S Pritzkow, SN Winter, DA Grear… - Biological …, 2020 - Wiley Online Library
Prions are misfolded infectious proteins responsible for a group of fatal neurodegenerative
diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic …

Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion

DM Henderson, KA Davenport… - Journal of General …, 2015 - microbiologyresearch.org
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies
through a process involving the templated conversion of the normal cellular prion protein …

Are we ready for detecting α-synuclein prone to aggregation in patients? The case of “protein-misfolding cyclic amplification” and “real-time quaking-induced …

S Paciotti, G Bellomo, L Gatticchi, L Parnetti - Frontiers in neurology, 2018 - frontiersin.org
The accumulation and deposition of α-synuclein aggregates in brain tissue is the main event
in the pathogenesis of different neurodegenerative disorders grouped under the term of …

Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear

NC Ferreira, JM Charco, J Plagenz, CD Orru… - Scientific reports, 2021 - nature.com
Efforts to contain the spread of chronic wasting disease (CWD), a fatal, contagious prion
disease of cervids, would be aided by the availability of additional diagnostic tools. RT-QuIC …

Evaluation of real-time quaking-induced conversion, ELISA, and immunohistochemistry for chronic wasting disease diagnosis

CL Holz, JR Darish, K Straka, N Grosjean… - Frontiers in Veterinary …, 2022 - frontiersin.org
Chronic wasting disease (CWD) is a transmissible prion disorder, primarily affecting free-
ranging and captive cervids in North America (United States and Canada), South Korea, and …

Chronic wasting disease: an evolving prion disease of cervids

SL Benestad, GC Telling - Handbook of clinical neurology, 2018 - Elsevier
Chronic wasting disease (CWD) is a relatively new and burgeoning prion epidemic of deer,
elk, reindeer, and moose, which are members of the cervid family. While the disease was …

Evolution of diagnostic tests for chronic wasting disease, a naturally occurring prion disease of cervids

NJ Haley, JA Richt - Pathogens, 2017 - mdpi.com
Since chronic wasting disease (CWD) was first identified nearly 50 years ago in a captive
mule deer herd in the Rocky Mountains of the United States, it has slowly spread across …

Comparison of conventional, amplification and bio-assay detection methods for a chronic wasting disease inoculum pool

E McNulty, AV Nalls, S Mellentine, E Hughes… - PloS one, 2019 - journals.plos.org
Longitudinal studies of chronic wasting disease (CWD) in the native host have provided
considerable understanding of how this prion disease continues to efficiently spread among …

Modified protein misfolding cyclic amplification overcomes real-time quaking-induced conversion assay inhibitors in deer saliva to detect chronic wasting disease …

KA Davenport, CE Hoover, ND Denkers… - Journal of clinical …, 2018 - Am Soc Microbiol
Chronic wasting disease (CWD), a fatal neurodegenerative prion disease of cervids, has
spread across North America and has been detected in The Republic of Korea, Finland, and …