Translation is a crucial step in gene expression and plays a vital role in regulating various
aspects of plant development and environmental responses. It is a dynamic and complex …

Nonsense mutations trigger premature translation termination and often give rise to
prevalent and rare genetic diseases. Consequently, the pharmacological suppression of an …

A crucial step in functional genomics is identifying actively translated ORFs and linking them
to biological functions. The challenge lies in identifying short ORFs, as their identification is …

The precise mechanisms by which plant viral proteases interact with and cleave host
proteins, thereby participating in virus–host interactions, are not well understood …

The crab-eating macaques (Macaca fascicularis) and rhesus macaques (M. mulatta) are
widely studied nonhuman primates in biomedical and evolutionary research. Despite their …

Termination codon readthrough (TCR) is a process in which ribosomes continue to translate
an mRNA beyond a stop codon generating a C-terminally extended protein isoform. Here …

ABSTRACT FEM1B is a substrate-recognition component of the CRL2 E3 ubiquitin-protein
ligase. This multi-protein complex targets specific proteins for ubiquitylation, which leads to …

Stop codon readthrough (SCR) has important biological implications but remains largely
uncharacterized. Here, we identify 1,009 SCR events in plants using a proteogenomic …

During translation, a stop codon on the mRNA signals the ribosomes to terminate the
process. In certain mRNAs, the termination fails due to the recoding of the canonical stop …

For several decades, it has been known that a substantial number of genes within human
DNA exhibit overlap; however, the biological and evolutionary significance of these overlaps …