Whereas the cellular basis of the hematopoietic stem cell (HSC) niche in the bone marrow
has been characterized, the nature of the fetal liver niche is not yet elucidated. We show that …

Profiling samples from patients, tissues, and cells with genomics, transcriptomics,
epigenomics, proteomics, and metabolomics ultimately produces lists of genes and proteins …

The immune system is a highly complex and dynamic system. Historically, the most common
scientific and clinical practice has been to evaluate its individual components. This kind of …

The genetic architecture of autism spectrum disorder involves the interplay of common and
rare variants and their impact on hundreds of genes. Using exome sequencing, here we …

Biological network analysis is a powerful approach to gain systems-level understanding of
patterns of gene expression in different cell types, disease states and other biological …

Abstract For the Library of Integrated Network-based Cellular Signatures (LINCS) project
many gene expression signatures using the L1000 technology have been produced. The …

Normal brain function depends on the interaction between highly specialized neurons that
operate within anatomically and functionally distinct brain regions. Neuronal specification is …

In vitro modeling of human disease has recently become feasible with induced pluripotent
stem cell (iPSC) technology. Here, we established patient-derived iPSCs from a Li-Fraumeni …

Data sets from recent large-scale projects can be integrated into one unified puzzle that can
provide new insights into how drugs and genetic perturbations applied to human cells are …

Pluripotency is increasingly recognized as a spectrum of cell states defined by their growth
conditions. Although naive and primed pluripotency states have been characterized …