Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies
Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …
The Multifunctional Family of Mammalian Fatty Acid–Binding Proteins
Fatty acid–binding proteins (FABPs) are small lipid-binding proteins abundantly expressed
in tissues that are highly active in fatty acid (FA) metabolism. Ten mammalian FABPs have …
in tissues that are highly active in fatty acid (FA) metabolism. Ten mammalian FABPs have …
[HTML][HTML] Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis
Abbreviations: ALT, alanine aminotransferase; BMI, body mass index; BODIPY‐C 12, 4, 4‐
difluoro‐5, 7‐dimethyl‐4‐bora‐3a, 4a‐diaza‐s‐Indacene‐3‐dodecanoic acid; ChIP …
difluoro‐5, 7‐dimethyl‐4‐bora‐3a, 4a‐diaza‐s‐Indacene‐3‐dodecanoic acid; ChIP …
Adipocyte fatty acid binding protein promotes the onset and progression of liver fibrosis via mediating the crosstalk between liver sinusoidal endothelial cells and …
X Wu, L Shu, Z Zhang, J Li, J Zong… - Advanced …, 2021 - Wiley Online Library
Abstract Development of liver fibrosis results in drastic changes in the liver
microenvironment, which in turn accelerates disease progression. Although the pathological …
microenvironment, which in turn accelerates disease progression. Although the pathological …
[HTML][HTML] SIRT6 protects against liver fibrosis by deacetylation and suppression of SMAD3 in hepatic stellate cells
X Zhong, M Huang, HG Kim, Y Zhang… - Cellular and molecular …, 2020 - Elsevier
Background & Aims Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is
manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The …
manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The …
[PDF][PDF] Sestrin 3 protects against diet‐induced nonalcoholic steatohepatitis in mice through suppression of transforming growth factor β signal transduction
Sestrin 3 (Sesn3) belongs to the three‐member sestrin protein family. Sestrins have been
implicated in antioxidative stress, adenosine monophosphate–activated protein kinase and …
implicated in antioxidative stress, adenosine monophosphate–activated protein kinase and …
Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice
P Yang, Y Wang, W Tang, W Sun, Y Ma, S Lin, J Jing… - Scientific Reports, 2020 - nature.com
Humans and rodents with Comparative Gene Identification-58 (CGI-58) mutations manifest
nonalcoholic fatty liver disease (NAFLD). Here we show that liver CGI-58 knockout (LivKO) …
nonalcoholic fatty liver disease (NAFLD). Here we show that liver CGI-58 knockout (LivKO) …
Emerging therapeutic potential of adeno-associated virus-mediated gene therapy in liver fibrosis
F Bu, P Jia, Y Zhu, Y Yang, H Meng, Y Bi… - … Therapy-Methods & …, 2022 - cell.com
Liver fibrosis is a wound-healing response that results from various chronic damages. If the
causes of damage are not removed or effective treatments are not given in a timely manner …
causes of damage are not removed or effective treatments are not given in a timely manner …
CGI-58: versatile regulator of intracellular lipid droplet homeostasis
L Yu, Y Li, A Grisé, H Wang - Lipid Transfer in Lipoprotein Metabolism and …, 2020 - Springer
Abstract Comparative gene identification-58 (CGI-58), also known as α/β-hydrolase domain-
containing 5 (ABHD5), is a member of a large family of proteins containing an α/β-hydrolase …
containing 5 (ABHD5), is a member of a large family of proteins containing an α/β-hydrolase …
Current advances in basic and translational research of cholangiocarcinoma
K Sato, L Baiocchi, L Kennedy, W Zhang, B Ekser… - Cancers, 2021 - mdpi.com
Simple Summary Cholangiocarcinoma (CCA) is highly malignant biliary tract cancer, which
is characterized by limited treatment options and poor prognosis. Basic science studies to …
is characterized by limited treatment options and poor prognosis. Basic science studies to …