Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …
are tremendous, the design and discovery of new candidates remain a time and cost …
Reading the repertoire: Progress in adaptive immune receptor analysis using machine learning
The adaptive immune system holds invaluable information on past and present immune
responses in the form of B and T cell receptor sequences, but we are limited in our ability to …
responses in the form of B and T cell receptor sequences, but we are limited in our ability to …
Broadly inhibitory antibodies to severe malaria virulence proteins
Malaria pathology is driven by the accumulation of Plasmodium falciparum-infected
erythrocytes in microvessels. This process is mediated by the polymorphic erythrocyte …
erythrocytes in microvessels. This process is mediated by the polymorphic erythrocyte …
Specific attributes of the VL domain influence both the structure and structural variability of CDR-H3 through steric effects
Antibodies, through their ability to target virtually any epitope, play a key role in driving the
adaptive immune response in jawed vertebrates. The binding domains of standard …
adaptive immune response in jawed vertebrates. The binding domains of standard …
Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses
H Chi, SQ Zhao, RY Chen, XX Suo, RR Zhang… - … and Targeted Therapy, 2024 - nature.com
The Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV),
remains a significant public health threat worldwide. The development of therapeutic …
remains a significant public health threat worldwide. The development of therapeutic …
[HTML][HTML] Broadly inhibitory antibodies against severe malaria virulence proteins
Plasmodium falciparum pathology is driven by the accumulation of parasite-infected
erythrocytes in microvessels. This process is mediated by the parasite's polymorphic …
erythrocytes in microvessels. This process is mediated by the parasite's polymorphic …
Nanobody paratope ensembles in solution characterized by MD simulations and NMR
ML Fernández-Quintero, EF DeRose, SA Gabel… - International Journal of …, 2022 - mdpi.com
Variable domains of camelid antibodies (so-called nanobodies or VHH) are the smallest
antibody fragments that retain complete functionality and therapeutic potential …
antibody fragments that retain complete functionality and therapeutic potential …
Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling
Immunoglobulin G (IgG) antibodies that bind their cognate antigen in a pH-dependent
manner (acid-switched antibodies) can release their bound antigen for degradation in the …
manner (acid-switched antibodies) can release their bound antigen for degradation in the …
Structure and Dynamics Guiding Design of Antibody Therapeutics and Vaccines
Antibodies and other new antibody-like formats have emerged as one of the most rapidly
growing classes of biotherapeutic proteins. Understanding the structural features that drive …
growing classes of biotherapeutic proteins. Understanding the structural features that drive …
Common framework mutations impact antibody interfacial dynamics and flexibility
Introduction With the flood of engineered antibodies, there is a heightened need to elucidate
the structural features of antibodies that contribute to specificity, stability, and breadth. While …
the structural features of antibodies that contribute to specificity, stability, and breadth. While …