Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

All life ends in death, but perhaps one of life's grander ironies is that it also depends on
death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for …

The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many
types of human cancer and are associated with chemoresistance, disease progression and …

Establishing and maintaining homeostasis is critical to the well-being of an organism and is
determined by the balance of cell proliferation and death. Two genes that function together …

The number of cells in an organism is determined by regulating both cell proliferation and
cell death. Relatively few mechanisms have been identified that can modulate both of these …

Misregulated innate immune signaling and cell death form the basis of much human disease
pathogenesis. Inhibitor of apoptosis (IAP) protein family members are frequently …

Proliferation and apoptosis must be precisely regulated to form organs with appropriate cell
numbers and to avoid tumour growth,. Here we show that Hippo (Hpo), the Drosophila …

Several of the inhibitor of apoptosis protein (IAP) family members regulate apoptosis in
response to various cellular assaults. Some members are also involved in cell signalling …

Apoptosis is a carefully orchestrated and tightly controlled form of cell death, conserved
across metazoans. As the executioners of apoptotic cell death, cysteine-dependent …