In untreated phenylketonuria (PKU), deficiency of phenylalanine hydroxylase (PAH) results
in elevated blood phenylalanine (Phe) concentrations and severe mental retardation …

Infantile spasms constitute an age-dependent epilepsy, highly associated with cognitive
impairment, autism, and movement disorders. Previous classification systems focused on a …

Classic phenylketonuria (PKU) is caused by defective activity of phenylalanine hydroxylase
(PAH), the enzyme that coverts phenylalanine (Phe) to tyrosine. Toxic accumulation of …

This manuscript reviews biological abnormalities shared by autism spectrum disorder (ASD)
and epilepsy. Two neuropathological findings are shared by ASD and epilepsy …

In phenylketonuria, mental retardation is prevented by a diet that severely restricts natural
protein and is supplemented with a phenylalanine-free amino acid mixture. The result is an …

The ability of a protein to fold into unique functional state or to stay intrinsically disordered is
encoded in its amino acid sequence. Both ordered and intrinsically disordered proteins …

Background Phenylketonuria (PKU) was the first disorder in which severe neurocognitive
dysfunction could be prevented by dietary treatment. However, despite this effect …

Classical phenylketonuria (PKU) is caused by deficiency of phenylalanine hydroxylase,
resulting in an accumulation of its upstream metabolite phenylalanine in brain tissue and …

This research reports the characterization of bee pollen of Apis andreniformis colonies on
the basis of morphology, proximate composition, the amino acid, and nutritive patterns in …

Previous studies have linked aspartame consumption to impaired retention of learned
behavior in rodents. Prenatal exposure to aspartame has also been shown to impair odor …