Mitochondria: their role in spermatozoa and in male infertility

M Boguenet, PE Bouet, A Spiers… - Human …, 2021 - academic.oup.com
BACKGROUND The best-known role of spermatozoa is to fertilize the oocyte and to transmit
the paternal genome to offspring. These highly specialized cells have a unique structure …

Mitochondria quality control and male fertility

J Costa, PC Braga, I Rebelo, PF Oliveira, MG Alves - Biology, 2023 - mdpi.com
Simple Summary Mitochondria play a crucial role in numerous cellular processes, including
energy production, apoptosis, and calcium homeostasis. In the male reproductive system …

[HTML][HTML] Call to action to properly utilize electron microscopy to measure organelles to monitor disease

K Neikirk, EG Lopez, AG Marshall, A Alghanem… - European Journal of …, 2023 - Elsevier
This review provides an overview of the current methods for quantifying mitochondrial
ultrastructure, including cristae morphology, mitochondrial contact sites, and recycling …

Cytoplasmic maturation in human oocytes: an ultrastructural study

Z Trebichalská, D Kyjovská, S Kloudová… - Biology of …, 2021 - academic.oup.com
Female fertility relies on successful egg development. Besides chromosome segregation,
complex structural and biochemical changes in the cytoplasmic compartment are necessary …

Motility assessment of ram spermatozoa

M Van de Hoek, JP Rickard, SP de Graaf - Biology, 2022 - mdpi.com
Simple Summary This review describes the mechanical and energetic processes which
underpin mammalian sperm motility as well as the mechanisms by which various agents …

ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility

K Shimada, S Park, H Miyata, Z Yu… - Proceedings of the …, 2021 - National Acad Sciences
The mammalian sperm midpiece has a unique double-helical structure called the
mitochondrial sheath that wraps tightly around the axoneme. Despite the remarkable …

Targeted antioxidant delivery modulates mitochondrial functions, ameliorates oxidative stress and preserve sperm quality during cryopreservation

S Tiwari, RK Dewry, R Srivastava, S Nath, TK Mohanty - Theriogenology, 2022 - Elsevier
Mitochondria are vital organelles with a multifaceted role in cellular bioenergetics,
biosynthesis, signaling and calcium homeostasis. During oxidative phosphorylation, sperm …

BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose …

L Li, B Chen, T An, H Zhang, B Xia, R Li, R Zhu… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Sperm infertility and testicular atrophy are symptoms
associated with aging. BaZiBuShen formula (BZBS), a patented Chinese herbal prescription …

Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis

S Mise, A Matsumoto, K Shimada, T Hosaka… - Nature …, 2022 - nature.com
Although several long noncoding RNAs (lncRNAs) have recently been shown to encode
small polypeptides, those in testis remain largely uncharacterized. Here we identify two …

Age-related decline of male fertility: mitochondrial dysfunction and the antioxidant interventions

JJ Wang, SX Wang, Y Feng, RF Zhang, XY Li, Q Sun… - Pharmaceuticals, 2022 - mdpi.com
Mitochondria are structurally and functionally unique organelles in male gametes.
Apparently, as the only organelles remaining in mature sperm, mitochondria not only …