Adult cortical areas consist of specialized cell types and circuits that support unique higher-
order cognitive functions. How this regional diversity develops from an initially uniform …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

A fundamental interest in developmental neuroscience lies in the ability to map the complete
single-cell lineages within the brain. To this end, we developed a CRISPR editing-based …

The differences in size and function between primate and rodent brains, and the association
of disturbed excitatory/inhibitory balance with many neurodevelopmental disorders highlight …

Highlights•The GEs produce many types of GABAergic projection neurons and a majority of
GABAergic interneurons.•Spatial origin, birthdate, and mode of division influence …

Understanding how neurons of the striatum are formed and integrate into complex synaptic
circuits is essential to provide insight into striatal function in health and disease. In this …

The ventral telencephalon is the developmental origin of the basal ganglia and the source of
neuronal and glial cells that integrate into developing circuits in other areas of the brain …

GABA is the key inhibitory neurotransmitter in the cortex but regulation of its synthesis during
forebrain development is poorly understood. In the telencephalon, members of the distal …

Large-scale regeneration in the adult central nervous system is a unique capacity of
salamanders among tetrapods. Salamanders can replace neuronal populations, repair …

First described by Ramon y Cajal as 'short‐axon'cells over a century ago, inhibitory
interneurons in the cerebral cortex make up~ 20–30% of the neuronal milieu. A key feature …