One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …

Axon regeneration holds great promise for neural repair of CNS axonopathies, including
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …

Highlights•Growth cone formation requires a precise actin and microtubule organization.•
Modulating cytoskeleton stability affects growth cone formation and axon elongation.• …

The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual
functional defects observed after traumatic injury, in degenerative diseases such as …

At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic
nerve to the brain. Available strategies of promoting axon regeneration act on only some of …

Mitochondrial transport is crucial for neuronal and axonal physiology. However, whether and
how it impacts neuronal injury responses, such as neuronal survival and axon regeneration …