Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

During the past decades, it became obvious that reactive oxygen species (ROS) exert a
multitude of biological effects covering a wide spectrum that ranges from physiological …

We present arguments for an evolution in our understanding of how antioxidants in fruits and
vegetables exert their health-protective effects. There is much epidemiological evidence for …

K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding,
but it also has an important role in sensing cellular stress. Recently, it has been shown that …

Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …

Hormesis is a term used by toxicologists to refer to a biphasic dose–response to an
environmental agent characterized by a low dose stimulation or beneficial effect and a high …

In the last 50 years, lipid peroxidation has been the subject of extensive studies from the
viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition …

Neurodegenerative disorders pose a significant health burden and imprint a debilitative
impact on the quality of life. Importantly, aging is intricately intertwined with the progression …

Monomers are released from dental resin materials, and thus cause adverse biological
effects in mammalian cells. Cytotoxicity and genotoxicity of some of these methacrylates …