The vascular endothelium has several important functions, including hemostasis. The
homeostasis of hemostasis is based on a fine balance between procoagulant and …

Tissue factor (TF), the major initiator of blood coagulation, serves as a regulator of
angiogenesis, tumor growth and metastasis. In several models, TF expression mediates …

Cell surface antigen CD109 is a glycosylphosphatidylinositol (GPI)–linked glycoprotein of
approximately 170 kd found on a subset of hematopoietic stem and progenitor cells and on …

To analyze the biological role of factor XII (FXII, Hageman Factor) in vivo, we generated mice
deficient for FXII using a gene targeting approach on two distinct genetic backgrounds, ie …

Recent advances in high-throughput molecular testing have made it possible to diagnose
most genetic disorders relatively early in gestation with minimal risk to the fetus. These …

OBJECTIVE: To evaluate factor XII deficiency in women with primary and secondary
recurrent abortion. DESIGN: Prospective case–control study. SETTING: University hospital …

Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-
million individuals worldwide. Persons with severe hemophilia A have coagulation FVIII …

AIM: To investigate over-expression of Osteopontin (OPN) pathway expression and
mechanisms of action in human alcoholic liver disease (ALD), in vivo and in vitro acute …

In the past six years, analysis of numerous murine models, enabled by investigator-
designed manipulation of the mouse genome, has generated an explosion of new, and …

ABSTRACT Plasminogen activator inhibitor (PAI)-2 expression is acutely upregulated in
pregnancy, inflammation, infection, and other pathophysiological conditions. Circumstances …