Acefylline (ACF) is a stimulant xanthine derivative drug, which is formulated as a piperazine
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …

Prothionamide (PRT) is used as an alternative to some first-line drugs in the treatment of
multi drug-resistant tuberculosis. Suffering from its extremely low water solubility and …

Tegafur (TGF) is a broad-spectrum anti-tumor drug, but it suffers from fast metabolism and
consequently poor oral absorption. Myricetin (MYR) is a flavonoid with anti-tumor activity …

Purpose The primary problem with climbazole (CLB), a broad-spectrum imidazole antifungal
drug, is its low water solubility. In order to increase its water solubility and antifungal activity …

An anti-solvent slurry method for cocrystal formation is developed and tested in 25
carbamazepine cocrystal systems. With a low solvent/anti-solvent volume ratio, it reduces …

Tioconazole is an effective antifungal agent, which has a very low solubility in aqueous
media, that limits its bioavailability and efficacy. In an effort to overcome the drug limitations …

The thermodynamic behavior of objective compounds plays an important role in
crystallization and purification. In this work, the solubility of climbazole in nine pure solvents …

In this work, the effectiveness of thermal methods, liquid-assisted grinding (LAG), and
crystallization by a slow evaporation technique for the screening of multicomponent crystals …

Trimethoprim (TMP) is a bacterial dihydroreductase inhibitor with broad-spectrum
antibacterial properties. However, its oral absorption is limited by its low water solubility …

Tioconazole is an effective antifungal agent with very low solubility in aqueous media, which
limits its bioavailability and efficacy. Aiming to overcome the drug limitations by improving …