Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

Over the past 15 years, elegant studies have demonstrated that in certain conditions,
programed cell death resembles necrosis and depends on a unique molecular pathway with …

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory
necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL …

Cadmium (Cd) is a toxic environmental pollutant and induces toxic effects to organism.
Nevertheless, the mechanism of Cd-induced toxicity in swine remains obscure. To explore …

Plastics are novel environmental pollutants with potential threats to the ecosystem. At least
5.25 trillion plastic particles in the environment, of which nanoplastics are< 100 nm in …

Programmed cell death (PCD) has been a major area of constantly growing interest over the
last three decades. Originally, apoptosis was considered the only mechanistic pathway for …

Most extracellular proteins are secreted via the classical endoplasmic reticulum (ER)/Golgi-
dependent secretion pathway; however, some proteins, including a few danger-associated …

Gut injury continues to be the devastating and unpredictable critical illness associated with
increased cell death of intestinal epithelial cells (IECs). The IECs, immune system and …

Necroptosis, a newly discovered form of programmed cell death that combines the features
of apoptosis and necrosis, is important in various physiological and pathological disorders …

Necroptosis is a lytic, proinflammatory cell death pathway, which has been implicated in host
defense and, when dysregulated, the pathology of many human diseases. The central …