Following embryo implantation, extravillous trophoblasts (EVTs) invade the maternal
decidua to a certain extent during early pregnancy, which is critical for normal placentation …

Myostatin (MSTN) is member of the transforming growth factor β (TGF-β) superfamily and
was originally identified in the musculoskeletal system as a negative regulator of skeletal …

Background Extravillous trophoblast (EVT) cell invasion is a tightly regulated process that
requires for a normal pregnancy. The epithelial-mesenchymal transition (EMT) has been …

Growth differentiation factor-8 (GDF-8) is a member of the transforming growth factor-beta
superfamily. Studies in vitro and in vivo have shown GDF-8 to be involved in the physiology …

Matrix metalloproteinases (MMPs) play a pivotal role in the regulation of cell invasion.
Placental trophoblast cell invasion is a precisely regulated event. Dysregulation of MMPs …

Growth differentiation factor 8 (GDF8) and its antagonist follistatin-like 3 (FSTL3) are
expressed in the placenta during early pregnancy. These two factors may have a role to play …

BACKGROUND During the human menstrual cycle and pregnancy, the endometrium
undergoes a series of dynamic remodeling processes to adapt to physiological changes …

BACKGROUND The placenta is a unique and pivotal organ in reproduction, controlling
crucial growth and cell differentiation processes that ensure a successful pregnancy …

Placental insufficiency disorders are major obstetric complications that share a common
phenomenon of poor placental trophoblast cell invasion and remodeling of uterine tissues …

Context: Myostatin is a highly conserved secretory protein that negatively regulates muscle
development by affecting both proliferation and differentiation of muscle cells. In human …