Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …

The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and
metabolism in response to nutrients, energy levels, and growth factors. It contains the …

Neurodegenerative diseases characterized by aberrant accumulation of undigested cellular
components represent unmet medical conditions for which the identification of actionable …

The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein
kinase, controls cell growth in response to nutrients and growth factors and is frequently …

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both
functions are dependent on the development of the senescent phenotype, which involves an …

Focal cortical dysplasia type II (FCDII) is a sporadic developmental malformation of the
cerebral cortex characterized by dysmorphic neurons, dyslamination and medically …

Abstract TOR (T arget O f R apamycin) is a highly conserved protein kinase that is important
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive …

Amino acids control cell growth via activation of the highly conserved kinase TORC1.
Glutamine is a particularly important amino acid in cell growth control and metabolism …

Genes encoding components of the PI3K–AKT–mTOR signaling axis are frequently mutated
in cancer, but few mutations have been characterized in MTOR, the gene encoding the …