Doxil®, the first FDA-approved nano-drug (1995), is based on three unrelated principles:(i)
prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano …

Although hydrophilic small molecule drugs are widely used in the clinic, their rapid
clearance, suboptimal biodistribution, low intracellular absorption and toxicity can limit their …

Extracellular vesicles (EVs) are membrane-derived particles surrounded by a (phospho)
lipid bilayer that are released by cells in the human body. In addition to direct cell-to-cell …

Urgent intervention is required to improve the 5 year survival rate of pancreatic ductal
adenocarcinoma (PDAC). While the four-drug regimen, FOLFIRINOX (comprising irinotecan …

Drug delivery research pursues many types of carriers including proteins and other
macromolecules, natural and synthetic polymeric structures, nanocarriers of diverse …

The therapeutic effectiveness of chemotherapy is optimal only when tumor cells are
subjected to a maximum drug exposure. To increase the intratumoral drug concentration …

Cell-based drug delivery systems are new strategies in targeted delivery in which cells or
cell-membrane-derived systems are used as carriers and release their cargo in a controlled …

As is widely suspected, lysolipid dissociation from liposomes contributes to the intravenous
instability of ThermoDox (lysolipid liposomes), thereby impeding its antitumor efficacy. This …

Computational chemistry applications have become an integral part of the drug discovery
workflow over the past 35 years. However, computational modeling in support of drug …

Most pharmaceutical formulation developments are complex and ideal formulations are
generally obtained after extensive experimentation. Machine learning is increasingly …