Camptothecin and its derivatives: Advancements, mechanisms and clinical potential in cancer therapy

M Kamle, S Pandhi, S Mishra, S Barua, A Kurian… - Medical Oncology, 2024 - Springer
Camptothecin (CPT), an alkaloid isolated from the Camptotheca tree, has demonstrated
significant anticancer properties in a range of malignancies. However, its therapeutic …

Biotechnology of camptothecin production in Nothapodytes nimmoniana, Ophiorrhiza sp. and Camptotheca acuminata

MK Swamy, S Nath, S Paul, NK Jha… - Applied Microbiology …, 2021 - Springer
Cancer is probably the deadliest human disease in recent years. In the past few years, rapid
clinical progress has been made in the field of anticancer drug development. Plant …

Enhanced camptothecin production induced by elicitors in the cell suspension cultures of Ophiorrhiza mungos Linn.

S Deepthi, K Satheeshkumar - Plant Cell, Tissue and Organ Culture …, 2016 - Springer
Production of camptothecin (CPT), an anticancer compound was enhanced in the cell
suspension cultures of Ophiorrhiza mungos Linn. through elicitor treatment. Cell suspension …

Cell line selection combined with jasmonic acid elicitation enhance camptothecin production in cell suspension cultures of Ophiorrhiza mungos L

S Deepthi, K Satheeshkumar - Applied Microbiology and Biotechnology, 2017 - Springer
Ophiorrhiza mungos is a herbaceous medicinal plant which contains a quinoline alkaloid,
camptothecin (CPT), an anticancer compound. A high-yielding cell line, O. mungos cell line …

Effects of major nutrients, growth regulators and inoculum size on enhanced growth and camptothecin production in adventitious root cultures of Ophiorrhiza mungos …

S Deepthi, K Satheeshkumar - Biochemical Engineering Journal, 2017 - Elsevier
Adventitious root cultures of medicinal plants are a source of secondary metabolites of
pharmaceutical importance. Ophiorrhiza mungos (Rubiaceae) contains a bioactive …

De novo transcriptome analyses reveals putative pathway genes involved in biosynthesis and regulation of camptothecin in Nothapodytes nimmoniana (Graham) …

GA Rather, A Sharma, SA Pandith, V Kaul… - Plant molecular …, 2018 - Springer
Key message Comprehensive transcriptome analysis of leaf and root tissues of
Nothapodytes nimmoniana unravels several putative pathway genes, transcription factors …

Genus Ophiorrhiza: A Review of Its Distribution, Traditional Uses, Phytochemistry, Biological Activities and Propagation

M Taher, SS Shaari, D Susanti, D Arbain, ZA Zakaria - Molecules, 2020 - mdpi.com
Almost 50 species of Ophiorrhiza plants were reviewed in this work and the main objective is
to critically analyse their distribution, phytochemical content, biological activity, and …

Biotechnology for micropropagation and camptothecin production in Ophiorrhiza sp.

DK Pandey, M Konjengbam, M Ghorai… - Applied Microbiology …, 2022 - Springer
Camptothecin (CPT) is a monoterpenoid-alkaloid, an anticancer compound from plant. Ever
since its discovery in 1996 from the bark of Camptotheca acuminata, various researches …

Enhancement of camptothecin biosynthesis in the green root cultures of Pyrenacantha volubilis Hook. under varied concentrations of ammonium nitrate and sucrose …

H Sasidharan, M Chembrakuniyil, S Krishnan - Industrial Crops and …, 2023 - Elsevier
Abstract Pyrenacantha volubilis Hook.(Icacinaceae) might be a touchstone for the in vitro
production of camptothecin, a high-value anti-cancer compound with an ever increasing …

Biotechnological approaches for the production of camptothecin

A Banadka, SW Narasimha, VS Dandin… - Applied Microbiology …, 2024 - Springer
Camptothecin (CPT), an indole alkaloid popular for its anticancer property, is considered the
third most promising drug after taxol and famous alkaloids from Vinca for the treatment of …