Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Skeletal muscle atrophy: From mechanisms to treatments
L Yin, N Li, W Jia, N Wang, M Liang, X Yang… - Pharmacological …, 2021 - Elsevier
Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started
to circulate among humans around December 2019, and it is now widespread as a global …
to circulate among humans around December 2019, and it is now widespread as a global …
Acoustic biosensors for ultrasound imaging of enzyme activity
Visualizing biomolecular and cellular processes inside intact living organisms is a major
goal of chemical biology. However, existing molecular biosensors, based primarily on …
goal of chemical biology. However, existing molecular biosensors, based primarily on …
Recent progress in the drug development targeting SARS-CoV-2 main protease as treatment for COVID-19
W Cui, K Yang, H Yang - Frontiers in molecular biosciences, 2020 - frontiersin.org
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2)
rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19) …
rapidly turned into an unprecedented pandemic of coronavirus disease 2019 (COVID-19) …
Dietary salt promotes cognitive impairment through tau phosphorylation
G Faraco, K Hochrainer, SG Segarra, S Schaeffer… - Nature, 2019 - nature.com
Dietary habits and vascular risk factors promote both Alzheimer's disease and cognitive
impairment caused by vascular factors,–. Furthermore, accumulation of …
impairment caused by vascular factors,–. Furthermore, accumulation of …
It's all about tau
C Tapia-Rojas, F Cabezas-Opazo, CA Deaton… - Progress in …, 2019 - Elsevier
Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …
bind and stabilize microtubules. However, it is now becoming evident that the functions of …
Exosomes secreted by endothelial cells derived from human induced pluripotent stem cells improve recovery from myocardial infarction in mice
H Li, L Wang, T Ma, Z Liu, L Gao - Stem cell research & therapy, 2023 - Springer
Background Human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs)
exhibit the potential to repair the injured heart after myocardial infarction (MI) by promoting …
exhibit the potential to repair the injured heart after myocardial infarction (MI) by promoting …
Out of control: the role of the ubiquitin proteasome system in skeletal muscle during inflammation
The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons
H Bogetofte, BJ Ryan, P Jensen, SI Schmidt… - Cell Reports, 2023 - cell.com
Variants at the GBA locus, encoding glucocerebrosidase, are the strongest common genetic
risk factor for Parkinson's disease (PD). To understand GBA-related disease mechanisms …
risk factor for Parkinson's disease (PD). To understand GBA-related disease mechanisms …