Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …

Many physiological changes occur with aging. These changes often, directly or indirectly,
result in a deterioration of the quality of life and even in a shortening of life expectancy …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of …

Normal repair of skeletal muscle requires local expansion of a special population of Foxp3+
CD4+ regulatory T (Treg) cells. Such cells failed to accumulate in acutely injured muscle of …

Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells)
that remain quiescent throughout life. Satellite cell regenerative functions decline with …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

World population has been continuously increasing and progressively aging. Aging is
characterized by a complex and intraindividual process associated with nine major cellular …

Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by
exposure to a young circulation, suggesting that young blood contains humoral …

Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …