Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …

The spatial organisation of the genome in the nucleus has a role in the regulation of gene
expression. In vertebrates, chromosomal regions with low gene-density are located close to …

Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear …

It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …

Lamins are components of the peripheral nuclear lamina and interact with heterochromatic
genomic regions, termed lamina-associated domains (LADs). In contrast to lamin B1 being …

Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

Emery-Dreifuss muscular dystrophy can be caused by mutations in the nuclear envelope
proteins lamin A/C and emerin. We recently demonstrated that A-type lamin-deficient cells …

A-and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in
a plethora of stable and transient interactions, near the inner nuclear membrane and …

A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents
of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein …