Transmission electron microscopy (EM) is a versatile technique that can be used to image
biological specimens ranging from intact eukaryotic cells to individual proteins> 150 kDa …

In macromolecular crystallography, radiation damage limits the amount of data that can be
collected from a single crystal. It is often necessary to merge data sets from multiple crystals; …

The aim of structural biology has been always the study of biological macromolecules
structures and their mechanistic behaviour at molecular level. To achieve its goal, multiple …

VMXi is a new high-flux microfocus macromolecular crystallography beamline at Diamond
Light Source. The beamline, dedicated to fully automated and fully remote data collection of …

Protein crystallography has significantly advanced in recent years, with in situ data
collection, in which crystals are placed in the X-ray beam within their growth medium, being …

Highlights•Drug discovery relies on quick and reliable MX experiments.•Innovation at
Diamond has increased throughput and quality of crystallographic data.•Diversification of …

The tangential curvature of actively bent X-ray mirrors at synchrotron radiation and X-ray free-
electron laser (XFEL) facilities is typically only changed every few hours or even days. This …

In situ diffraction data collection using crystallization plates has been utilized for
macromolecules to evaluate crystal quality without requiring additional sample treatment …

In recent years, in situ data collection has been a major focus of progress in protein
crystallography. Here, we introduce the Mylar in situ method using Mylar-based sandwich …

Sample handling and manipulation for cryoprotection currently remain critical factors in X-
ray structural determination. While several microchips for macromolecular crystallization …