Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review
S Masyeni, M Iqhrammullah… - Journal of Medical …, 2022 - Wiley Online Library
Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp)
are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 …
are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 …
A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval
NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
The rising outbreak of SARS-CoV-2 continues to unfold all over the world. The development
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus
Seasonal human influenza is a serious respiratory infection caused by influenza viruses that
can be found all over the world. Type A influenza is a contagious viral infection that, if left …
can be found all over the world. Type A influenza is a contagious viral infection that, if left …
Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: In silico and in vitro studies
In this study, a series of 1, 3, 4-oxadiazoles carrying the isatin moiety (IVa–g) as anti-SARS-
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …
Bioactive Azadirachta indica and Melia azedarach leaves extracts with anti-SARS-CoV-2 and antibacterial activities
BA Hemdan, A Mostafa, MM Elbatanony, AM El-Feky… - PLoS …, 2023 - journals.plos.org
The leaves of Azadirachta indica L. and Melia azedarach L., belonging to Meliaceae family,
have been shown to have medicinal benefits and are extensively employed in traditional folk …
have been shown to have medicinal benefits and are extensively employed in traditional folk …
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies
A Abo Elmaaty, WM Eldehna, M Khattab… - International Journal of …, 2022 - mdpi.com
In this article, 34 anticoagulant drugs were screened in silico against the main protease
(Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux …
(Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux …
Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti …
Pirfenidone (PFD) is a non-peptide synthetic chemical that inhibits the production of
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS …
The global outbreak of the COVID-19 pandemic provokes scientists to make a prompt
development of new effective therapeutic interventions for the battle against SARS-CoV-2. A …
development of new effective therapeutic interventions for the battle against SARS-CoV-2. A …
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and …
Abstract Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy.
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Identification of natural lead compounds against hemagglutinin-esterase surface glycoprotein in human coronaviruses investigated via MD simulation, principal …
The pandemic outbreak of human coronavirus is a global health concern that affects people
of all ages and genders, but there is currently still no effective, approved and potential drug …
of all ages and genders, but there is currently still no effective, approved and potential drug …