Rapid, sensitive, precise and accurate analysis of samples in their native in vivo
environment is critical to better decipher physiological and physiopathological mechanisms …

Histopathological diagnosis of biopsy samples and margin assessment of surgical
specimens are challenging aspects in sarcoma. Using dog patient tissues, we assessed the …

In this study, we conducted a direct comparison of water-assisted laser desorption ionization
(WALDI) and matrix-assisted laser desorption ionization (MALDI) mass spectrometry …

Oral cavity cancers are the 15th most common cancer with more than 350,000 new cases
and~ 178,000 deaths each year. Among them, squamous cell carcinoma (SCC) accounts for …

Rationale The level of visual detail of a mass spectrometry image is dependent on the
spatial resolution with which it is acquired, which is largely determined by the focal diameter …

Tumor cell percentage (TCP) is an essential characteristic of biopsy samples that directly
affects the sensitivity of molecular testing in clinical practice. Apart from clarifying diagnoses …

This paper covers direct sub‐atmospheric pressure ionization mass spectrometry (MS). The
discovery, applications, and mechanistic aspects of novel ionization processes for use in MS …

By the on-chip integration of a droplet generator in front of an emitter tip, droplets of non-
polar solvents are generated in a free jet of an aqueous matrix. When an IR laser irradiates …

Water-assisted laser desorption/ionization mass spectrometry (WALDI-MS), also known as
SpiderMass, is an emerging ambient ionization technique for in vivo and real-time analysis …

We previously demonstrated that remote infrared Matrix Assisted Laser Desorption
Ionization technology (Spidermass) using endogenous water as matrix (or so called water …