RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases

CR Harrell, N Jovicic, V Djonov, N Arsenijevic… - Cells, 2019 - mdpi.com
There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression
was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC …

Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury

ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …

Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury

S Guo, N Perets, O Betzer, S Ben-Shaul, A Sheinin… - ACS …, 2019 - ACS Publications
Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits,
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …

Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm

K Yin, S Wang, RC Zhao - Biomarker research, 2019 - Springer
Mesenchymal stem/stromal cells (MSCs) have been demonstrated to hold great potential for
the treatment of several diseases. Their therapeutic effects are largely mediated by …

Dysmaturation of premature brain: importance, cellular mechanisms, and potential interventions

JJ Volpe - Pediatric neurology, 2019 - Elsevier
Prematurity, especially preterm birth (less than 32 weeks' gestation), is common and
associated with high rates of both survival and neurodevelopmental disability, especially …

Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury

G Thomi, D Surbek, V Haesler… - Stem cell research & …, 2019 - Springer
Background Preterm newborns are at high risk of developing neurodevelopmental deficits
caused by neuroinflammation leading to perinatal brain injury. Human Wharton's jelly …

Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

R Upadhya, W Zingg, S Shetty, AK Shetty - Journal of controlled release, 2020 - Elsevier
Extracellular vesicles (EVs) released by neural cells play an essential role in brain
homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse …

Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

A Nagelkerke, M Ojansivu, L van der Koog… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting
as delivery vehicles for molecular messages. During the last decade, EVs have been …