Abstract Tumor Necrosis Factor (TNF), initially known for its tumor cytotoxicity, is a potent
mediator of inflammation, as well as many normal physiological functions in homeostasis …

DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these
agents induce a plethora of different DNA lesions, it is firstly important to identify the specific …

The gram-positive bacterium Listeria monocytogenes is the causative agent of listeriosis, a
highly fatal opportunistic foodborne infection. Pregnant women, neonates, the elderly, and …

Sphingolipid metabolites participate in key events of signal transduction and cell regulation.
In the sphingomyelin cycle, a number of extracellular agents and insults (such as tumor …

Interleukin-I (IL-1) is the prototypic pro-inflammatory cytokine. There are two forms of IL-1, IL-
1α and IL-Iβ and in most studies, their biological activities are indistinguishable. IL-1 affects …

The past few years have provided substantial evidence for the vital role of the local tumor
microenvironment for various aspects of tumor progression. With obesity and its …

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the
molecules that induce and regulate immune responses. Now expanded to two volumes, co …

The Toll/interleukin-1 (IL-1) receptor (TIR) family comprises two groups of transmembrane
proteins, which share functional and structural properties. The members of the IL-1 receptor …

Listeria monocytogenes secretes two distinct phospholipases C, a phosphatidylinositol-
specific phospholipase C (PI-PLC) and a broad-range phospholipase C (PC-PLC). In this …

Objective Proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and
interleukin (IL)-1 beta have been implicated in the pathogenesis of myocardial dysfunction in …